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Second, central nervous system signaling: GLP-1 receptors in the brain, particularly in the area postrema (the brain's vomiting center), contribute to nausea independent of what's happening in the stomach

Interestingly, its been shown that combining metformin with vitamin D seems to enhance the positive effects of metformin, including reducing thyroid antibodies, improving insulin sensitivity, and improving thyroid hormone levels

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You can also take L-Carnitine with meals to support overall energy metabolism throughout the day

Viercinski R, Snively D